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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Morusin, TNF-related apoptosis inducing ligand
Phytochemical Name Morusin (PubChem CID: 5281671 )
Anticancer drug Name TNF-related apoptosis inducing ligand (PubChem CID: / )
Structure of
Phytochemical		 2D-img
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2D MOL 3D MOL
Structure of
Anticancer Drug		 2D-img
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Decreasing Drug Toxicity
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Combination Pair ID: 659
Ref_1
Pair Name Morusin, TNF-related apoptosis inducing ligand
Disease Info [ICD-11: 2A00] Glioblastoma multiforme Investigative
Biological Phenomena Induction-->Apoptosis
Gene Regulation Up-regulation Expression TNFRSF10B hsa8795
Down-regulation Expression BIRC5 hsa332
Down-regulation Expression XIAP hsa331
Down-regulation Expression EGFR hsa1956
Down-regulation Phosphorylation STAT3 hsa6774
In Vitro Model U-251MG Astrocytoma Homo sapiens (Human) CVCL_0021
LN-18 Glioblastoma Homo sapiens (Human) CVCL_0392
Result These results suggest that morusin enhances TRAIL sensitivity in human glioblastoma cells through regulating expression of DR5 and EGFR. Therefore, the combination treatment of TRAIL and morusin may be a new therapeutic strategy for malignant glioma patients.
03. Reference
No. Title Href
1 Morusin Induces TRAIL Sensitization by Regulating EGFR and DR5 in Human Glioblastoma Cells. J Nat Prod. 2016 Feb 26;79(2):317-23. doi: 10.1021/acs.jnatprod.5b00919. Click
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